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FLASH GENE
Symbol IGHA1 contributors: npt - updated : 17-06-2006
HGNC name immunoglobulin heavy constant alpha 1
HGNC id 5478
Location 14q32.33      Physical location : -
Synonym name
  • including a locus control region, see LCR-IGHA1
  • Ig alpha-1 chain C region
    • Synonym symbol(s) FLJ35075, FLJ40001, IGA1, FLJ14473, FLJ35065, FLJ35500, FLJ36402, FLJ39698, FLJ40001, FLJ41548, FLJ41552, FLJ41789, FLJ43248, FLJ43594, FLJ44293, FLJ46028, FLJ46621, FLJ46724, FLJ46811, FLJ46824, MGC102857
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text including a locus control region, see LCR- IGHA1
    STRUCTURE 1.00 kb     0 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     tonsils   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Ig-like (immunoglobulin-like) domains
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin C-type family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • antigen binding
  • major immunoglobulin class in body secretions
  • may serve both to defend against local infection
    • and to prevent access of foreign antigens to the general
    immunologic system
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an homodimer of two D heavy chains bound by an unique disulfide bond
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS