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FLASH GENE

Symbol

TBL1Y

contributors: mct - updated : 01-09-2020

HGNC name	transducin (beta)-like 1Y-linked
HGNC id	18502

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   highly Homo sapiens Reproductive male system prostate       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a F-box-like domain
	a LISH domain
	eight WD repeats

HOMOLOGY

intraspecies

homolog to TBL1X

Homologene

FAMILY

WD repeat EBI family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in signal transduction, RNA processing, gene regulation, vesicular trafficking
	playing a role in the maleness
	TBL1Y is involved in the genesis of non-syndromic coarctation of the aorta

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	could be considered a novel candidate for Hereditary hearing loss (HHL)
Marker
Therapy target

ANIMAL & CELL MODELS