basic FUNCTION
| involved in transcription regulation |
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TBPL2 and TAF3 are likely also required for hematopoiesis initiation |
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TBP-associated core promoter factor, that is highly enriched in ES cells |
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is required for endoderm lineage differentiation and prevents premature specification of neuroectoderm and mesoderm |
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role of TAF3 in mediating long-range chromatin regulatory interactions that safeguard the finely-balanced transcriptional programs underlying pluripotency |
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TAF3, and associated H3K4me3 interactions, have a direct role in gene-specific regulation within the TP53 network |
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H3K4me3, through TAF3 interactions, can act either independently or cooperatively with the TATA box to direct preinitiation complex (PIC) formation and transcription |
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is required for normal erythropoiesis and it might have a role in controlling the ratio between hemoglobin (Hb) and cell volume and in the dynamics of RBC maturation in healthy individuals |
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PHD-finger of TAF3 is important for rapid induction of target genes |