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FLASH GENE

Symbol

STK38

contributors: mct - updated : 31-05-2014

HGNC name	serine/threonine kinase 38
HGNC id	17847

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   resulted in centrosome overduplication in a kinase-activity-dependent manner, while expression of kinase-dead STK38/STK38L or depletion of STK38/STK38L by small interfering RNA (siRNA) negatively affected centrosome duplication

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis, thus providing a novel viable target for treating B-cell lymphomas

ANIMAL & CELL MODELS