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FLASH GENE
Symbol IFIT2 contributors: mct - updated : 21-02-2017
HGNC name interferon-induced protein with tetratricopeptide repeats 2
HGNC id 5409
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • 9 tetratricopeptide repeat-like motifs and associate to form domain-swapped dimers
  • C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface
    • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFIT family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • role of IFIT2 in the induction of apoptosis via a mitochondrial pathway
  • is one of the most highly responsive interferon-stimulated genes
  • may prevent oral squamous cell carcinoma (OSCC) metastasis
  • IFIT1 and IFIT2 contribute significantly to the regulation of HBV replication, likely at both transcriptional and posttranscriptional steps
  • IFN-stimulated IFIT2 via enhanced IRF3 phosphorylation upregulates the secretion of proinflammatory cytokines
  • is the interferon-induced protein that prevents vesicular stomatitis virus (VSV) infection of neurons of both the peripheral and the central nervous systems, thus inhibiting the consequent neuropathy, but it is dispensable for protecting the cells of other tissues from VSV infection
  • specific interferon-induced protein, IFIT2, is the protein that protects neurons from VSV infection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFIT3 binding negatively regulates the apoptotic effects of IFIT2
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
  • AJUBA represses the expression of IFIT2 gene, an interferon-stimulated gene and a known apoptosis inducer and tumour suppressor to mediate its resistance to apoptosis
    • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interferon beta,interleukin 1,retinoic acid,viral infections…
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • valuable prognostic marker in oral squamous cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS
  • in Ifit2(-/-) mice, vesicular stomatitis virus (VSV), injected subcutaneously into the footpad, entered the proximal lymph node, where it replicated and infected the nodal nerve endings