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FLASH GENE
Symbol SPACA1 contributors: mct - updated : 30-08-2022
HGNC name sperm acrosome associated 1
HGNC id 14967
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a potential transmembrane domain in the C-terminus
  • an N-terminal domain homologous to the major malarial circumsporozoite surface protein
  • a domain similar to that of Krp1 from Schizosaccharomyces pombe in its carboxyl terminus
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast S.pombe Krp1
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • acrosomal membrane of spermatids and mature spermatozoa
  • localizes in the equatorial segment of spermatozoa in mammals
    • basic FUNCTION
  • playing a role in acrosomal morphogenesis and in sperm-egg binding and fusion
  • membrane protein reported to function in sperm-egg fusion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to egg (oocyte)
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF74
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in patients with globozoospermia
    constitutional       loss of function
    disruption of SPACA1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Spaca1 gene-disrupted mice have abnormally shaped sperm heads that resemble those of human globozoospermia