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FLASH GENE
Symbol SPACA1 contributors: mct - updated : 30-08-2022
HGNC name sperm acrosome associated 1
HGNC id 14967
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa Homo sapiens
cell lineage spermatids
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a potential transmembrane domain in the C-terminus
  • an N-terminal domain homologous to the major malarial circumsporozoite surface protein
  • a domain similar to that of Krp1 from Schizosaccharomyces pombe in its carboxyl terminus
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast S.pombe Krp1
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • acrosomal membrane of spermatids and mature spermatozoa
  • localizes in the equatorial segment of spermatozoa in mammals
    • basic FUNCTION
  • playing a role in acrosomal morphogenesis and in sperm-egg binding and fusion
  • membrane protein reported to function in sperm-egg fusion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to egg (oocyte)
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF74
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in patients with globozoospermia
    constitutional       loss of function
    disruption of SPACA1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Spaca1 gene-disrupted mice have abnormally shaped sperm heads that resemble those of human globozoospermia