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FLASH GENE

Symbol

SPACA1

contributors: mct - updated : 30-08-2022

HGNC name	sperm acrosome associated 1
HGNC id	14967

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	19.94 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030960 7 - 1501 NP_112222 - 294 - 2002 11870081

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatozoa Homo sapiens

cell lineage	spermatids
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a potential transmembrane domain in the C-terminus
	an N-terminal domain homologous to the major malarial circumsporozoite surface protein
	a domain similar to that of Krp1 from Schizosaccharomyces pombe in its carboxyl terminus

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to yeast S.pombe Krp1

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
text	acrosomal membrane of spermatids and mature spermatozoa
	localizes in the equatorial segment of spermatozoa in mammals

basic FUNCTION	playing a role in acrosomal morphogenesis and in sperm-egg binding and fusion
	membrane protein reported to function in sperm-egg fusion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

binding to egg (oocyte)

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF74

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in patients with globozoospermia constitutional       loss of function disruption of SPACA1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Spaca1 gene-disrupted mice have abnormally shaped sperm heads that resemble those of human globozoospermia