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FLASH GENE
Symbol SP8 contributors: np - updated : 09-06-2005
HGNC name Sp8 transcription factor
HGNC id 19196
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • three C2H2-type zinc fingers
    • HOMOLOGY
    interspecies homolog to Drosophila btd
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating mRNA synthesis from genes that contain functional recognition sites
  • is required during corticogenesis to sustain a normal progenitor pool, and to control preplate splitting, as well as the specification of cellular diversity (Zembrzycki 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds to GC box promoters elements
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS