Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SP8 contributors: np - updated : 09-06-2005
HGNC name Sp8 transcription factor
HGNC id 19196
Location 7p21.1      Physical location : 20.821.894 - 20.826.508
Synonym name
  • specificity protein 8
  • nuttonhead, Drosophila, homolog of
  • Synonym symbol(s) BTD
    DNA
    TYPE functioning gene
    STRUCTURE 4.62 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TWISTNB 7p21 TWIST neighbor MGC42090 7p21.1 hypothetical protein MGC42090 PEG10 7q21 paternally expressed 10 7A5 7p15.3 putative binding protein 7a5 LOC392955 7 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC392956 7 similar to dJ133P16.1 (ADP-ribosylation factor 1) ITGB8 7p integrin, beta 8 PPP1R9A 7q21 protein phosphatase 1, regulatory (inhibitor) subunit 9A TM4SF12 7 transmembrane 4 superfamily member 12 7A5 7p15.3 putative binding protein 7a5 LOC392870 7 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati ING3 7q31 inhibitor of growth family, member 3 ABCB5 7p14 ATP-binding cassette, sub-family B (MDR/TAP), member 5 FLJ21986 7q31.32 hypothetical protein FLJ21986 ITGB8 7p integrin, beta 8 PON1 7q21.3 paraoxonase 1 SP8 7p21.2 Sp8 transcription factor PON3 7q21.3 paraoxonase 3 LOC392640 7 similar to ribosomal protein L23 PON2 7q21.3 paraoxonase 2 LOC392003 7 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati ASB4 7q21-q22 ankyrin repeat and SOCS box-containing 4 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C ABCB5 7p14 ATP-binding cassette, sub-family B (MDR/TAP), member 5 PDK4 7q21.3 pyruvate dehydrogenase kinase, isoenzyme 4 LOC392749 7 LOC392749 LOC392978 7 similar to Cytochrome c, somatic LOC392979 7 similar to ribosomal protein L18; 60S ribosomal protein L18 SP8 7p21.2 Sp8 transcription factor LOC222901 7p15.3 similar to ribosomal protein L23 LOC392871 7 similar to argininosuccinate synthetase DNCI1 7q21.3 dynein, cytoplasmic, intermediate polypeptide 1 SP4 7p15.2-p14 Sp4 transcription factor PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 DNAH11 7p15 dynein, axonemal, heavy polypeptide 11 SLC25A13 7q21.3 solute carrier family 25, member 13 (citrin) LOC340274 7p15.3 similar to argininosuccinate synthetase AASS 7q31.3 aminoadipate-semialdehyde synthase RNU1P8 7p15.3 RNA, U1 small nuclear pseudogene 8 SP4 7p15.2-p14 Sp4 transcription factor LOC392980 7 similar to ribosomal protein L31 RAM2 7p15.3 transcription factor RAM2 DNAH11 7p15 dynein, axonemal, heavy polypeptide 11 LOC392779 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 GFR 7p21.3 Ca2+-dependent activator protein for secretion 2 SHFM1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 3642 - 508 - Milona (2004)
    3 splicing 3738 - 490 - Milona (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • three C2H2-type zinc fingers
  • HOMOLOGY
    interspecies homolog to Drosophila btd
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating mRNA synthesis from genes that contain functional recognition sites
  • is required during corticogenesis to sustain a normal progenitor pool, and to control preplate splitting, as well as the specification of cellular diversity (Zembrzycki 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds to GC box promoters elements
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS