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FLASH GENE
Symbol SNX8 contributors: SGE/npt - updated : 18-01-2010
HGNC name sorting nexin 8
HGNC id 14972
Location 7p22.3      Physical location : 2.294.640 - 2.354.099
Synonym symbol(s) Mvp1
DNA
TYPE functioning gene
STRUCTURE 59.46 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
EIF3S9 7p22.3 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa LOC392928 7 similar to zinc finger protein 92 (HTF12) KIAA0010 7q36.3 ubiquitin-protein isopeptide ligase (E3) MGC35361 7q22.1 hypothetical protein MGC35361 CHST12 7p22 carbohydrate (chondroitin 4) sulfotransferase 12 LOC392736 7 similar to deltex 2 MGC21636 LOC392857 7 similar to galectin-related inter-fiber protein LOC392737 7 hypothetical gene supported by AK024602 LOC392699 7 hypothetical gene supported by BT007161; NM_006761 LOC392738 7 similar to PMS4 homolog mismatch repair protein - human LOC392618 7 similar to Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) LOC392739 7 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) C7orf27 7p22.3 chromosome 7 open reading frame 27 LRRC17 7q22 leucine rich repeat containing 17 KIAA1023 7p22.3 KIAA1023 protein LOC392929 7 similar to hypothetical protein FLJ90430 DNAJB6 7q36.3 DnaJ (Hsp40) homolog, subfamily B, member 6 FLJ90430 7q11.21 hypothetical protein FLJ90430 FTSJ2 7p22 FtsJ homolog 2 (E. coli) NUDT1 7p22 nudix (nucleoside diphosphate linked moiety X)-type motif 1 LOC392619 7 similar to KIAA1691 protein SNX8 7p22.3 sorting nexin 8 FGL2 7q11.2 fibrinogen-like 2 LOC392930 7 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) KIAA1950 7p22.3 KIAA1950 protein LOC393078 7 similar to polycystic kidney disease 1-like 3 SVH 7q22.1 SVH protein LOC392620 7 LOC392620 GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 EIF3S9 7p22.3 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa NAPE-PLD 7q22.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D LOC392851 7 hypothetical gene supported by AK098637 LOC54103 7q21.11 hypothetical protein LOC54103 ZFD25 7q11.2 hypothetical protein LOC54103 PTPRN2 7q36 protein tyrosine phosphatase, receptor type, N polypeptide 2 CHST12 7p22 carbohydrate (chondroitin 4) sulfotransferase 12 LOC392968 7 similar to 60S ribosomal protein L23a LOC392943 7 similar to hypothetical protein FLJ36166 7q22.1 hypothetical protein FLJ36166 LOC392700 7 similar to myelin protein zero-like 1; protein zero related
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1522 15.44 465 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PX domain (phosphoinositide binding domain)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Snx8 (89.5pc)
    homolog to murine Snx8 (89.5pc)
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • involved in endosomal sorting (Dyve 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS