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FLASH GENE

Symbol

SMPD2

contributors: mct - updated : 15-10-2010

HGNC name	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
HGNC id	11121

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

neutral sphingomyelinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
text	mitochondria-associated nSMase (MA-nSMase)

basic FUNCTION	converting sphingomyelin to ceramide
	one of the key enzymes involved in the generation of ceramide
	having role in aging and inflammation
	acts primarily as lyso-platelet-activating factor-phospholipase C (Marchesini 2003)
	played a role in daunorubicin-induced cell death
	may increase dopamine uptake through inducing ceramide production and thereby decreasing intracellular calcium levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	activity was dependent on Mg(2+)

protein

cell & other

REGULATION

activated by

phosphatidylserine

Other

regulation through a redox glutathione-dependent mechanism

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function occurs in aging and it underlies the hepatic IL1b hyperresponsiveness

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS