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FLASH GENE
Symbol SMPD2 contributors: mct - updated : 15-10-2010
HGNC name sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
HGNC id 11121
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemmale genital tractepididymis highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • neutral sphingomyelinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text
  • mitochondria-associated nSMase (MA-nSMase)
    • basic FUNCTION
  • converting sphingomyelin to ceramide
  • one of the key enzymes involved in the generation of ceramide
  • having role in aging and inflammation
  • acts primarily as lyso-platelet-activating factor-phospholipase C (Marchesini 2003)
  • played a role in daunorubicin-induced cell death
  • may increase dopamine uptake through inducing ceramide production and thereby decreasing intracellular calcium levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • activity was dependent on Mg(2+)
    • protein
    cell & other
    REGULATION
    activated by phosphatidylserine
    Other regulation through a redox glutathione-dependent mechanism
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    occurs in aging and it underlies the hepatic IL1b hyperresponsiveness
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS