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FLASH GENE
Symbol SLC6A11 contributors: mct/npt - updated : 12-12-2009
HGNC name solute carrier family 6 (neurotransmitter transporter, GABA), member 11
HGNC id 11044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Slc6a11
homolog to murine Gabt4
Homologene
FAMILY
  • sodium, neurotransmitter symporter (SNF) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • terminating the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals
  • may be involved in genetic susceptibility to treatment-resistant neuroleptic-induced tardive dyskinesia , at least in a subgroup of patients with schizophrenia (Inada 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by zinc, playing a role in modulating the balance between excitatory and inhibitory synaptic transmission
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS