Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC2A4RG contributors: - updated : 12-10-2005
HGNC name SLC2A4 regulator
HGNC id 15930
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFC domain
  • a nuclear localization signal,
  • nuclear export signal,
  • zinc finger, serine/proline-rich region,
  • highly conserved C-terminal region
    • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shift from cytoplasm to nucleus by the treatment with an inhibitor of the nuclear export, leptomycin B, and mutagenesis of the putative nuclear export signals
    basic FUNCTION
  • regulating the GLUT4 promoter
  • transcription factors shuttling between nucleus and cytoplasm and binding to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC2A4 and MEF2A (activating SLC2A4 transcription)
  • binding to the promoter region for the HD gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS