Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC2A4RG contributors: - updated : 12-10-2005
HGNC name SLC2A4 regulator
HGNC id 15930
Location 20q13.33      Physical location : 62.371.210 - 62.375.401
Genatlas name GLUT4 enhancer factor
Synonym name Huntington's disease gene regulatory region-binding protein 1
Synonym symbol(s) GEF, HDBP1, Si-1-2
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KIAA1510 20q13.33 KIAA1510 protein CHRNA4 20q13.2-q13.3 cholinergic receptor, nicotinic, alpha polypeptide 4 KCNQ2 20q13.3 potassium voltage-gated channel, KQT-like subfamily, member 2 EEF1A2 20q13.3 eukaryotic translation elongation factor 1 alpha 2 LOC149659 20q13.33 hypothetical LOC149659 C20orf149 20q13.33 chromosome 20 open reading frame 149 PTK6 20q13.3 PTK6 protein tyrosine kinase 6 SRMS 20q13.33 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites MGC5356 20q13.33 hypothetical protein MGC5356 PRIC285 20q13.33 peroxisomal proliferator-activated receptor A interacting complex 285 LOC200213 20q13.33 hypothetical protein LOC200213 GMEB2 20q13.33 glucocorticoid modulatory element binding protein 2 LOC388807 20 LOC388807 STMN3 20q13.3 stathmin-like 3 C20orf41 20q13.3 chromosome 20 open reading frame 41 TNFRSF6B 20q13.3 tumor necrosis factor receptor superfamily, member 6b, decoy ARFRP1 20q13.3 ADP-ribosylation factor related protein 1 KIAA1847 20q13.3 KIAA1847 FLJ20406 20q13.3 hypothetical protein FLJ20406 SLC2A4RG 20q13.33 SLC2A4 regulator FLJ20825 20q13.33 hypothetical protein FLJ20825 C20orf135 20q13.33 chromosome 20 open reading frame 135 TPD52L2 20q13.2-q13.3 tumor protein D52-like 2 LOC388808 20 LOC388808 URKL1 20q13.33 uridine kinase-like 1 KIAA1196 20q13.33 KIAA1196 protein C20orf136 20q13.33 chromosome 20 open reading frame 136 C20orf14 20q13.33 chromosome 20 open reading frame 14
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart    
Endocrinethyroid    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialsecretoryglandularendocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFC domain
  • a nuclear localization signal,
  • nuclear export signal,
  • zinc finger, serine/proline-rich region,
  • highly conserved C-terminal region
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shift from cytoplasm to nucleus by the treatment with an inhibitor of the nuclear export, leptomycin B, and mutagenesis of the putative nuclear export signals
    basic FUNCTION
  • regulating the GLUT4 promoter
  • transcription factors shuttling between nucleus and cytoplasm and binding to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC2A4 and MEF2A (activating SLC2A4 transcription)
  • binding to the promoter region for the HD gene
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS