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FLASH GENE

Symbol

SLC2A4RG

contributors: - updated : 12-10-2005

HGNC name	SLC2A4 regulator
HGNC id	15930

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.33      Physical location : 62.371.210 - 62.375.401
Genatlas name	GLUT4 enhancer factor
Synonym name	Huntington's disease gene regulatory region-binding protein 1
Synonym symbol(s)	GEF, HDBP1, Si-1-2

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Cardiovascular heart         Endocrine thyroid         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial secretory glandular endocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one VWFC domain
	a nuclear localization signal,
	nuclear export signal,
	zinc finger, serine/proline-rich region,
	highly conserved C-terminal region

mono polymer

homomer , trimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	shift from cytoplasm to nucleus by the treatment with an inhibitor of the nuclear export, leptomycin B, and mutagenesis of the putative nuclear export signals

basic FUNCTION	regulating the GLUT4 promoter
	transcription factors shuttling between nucleus and cytoplasm and binding to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SLC2A4 and MEF2A (activating SLC2A4 transcription)
	binding to the promoter region for the HD gene

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS