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FLASH GENE

Symbol

FCGR2A

contributors: mct - updated : 21-06-2017

HGNC name	Fc fragment of IgG, low affinity IIa, receptor (CD32)
HGNC id	3616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to glomerulonephritis in Caucasoid patients with lupus erythematosus to acute coronary syndromes (ACS) to severe falciparum malaria to Kawasaki disease to Takayasu arteritis

Variant & Polymorphism SNP	Fc gamma RIIa-H/R131, over-represented
	association of the R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease
	FCGR2a131RR positively associated with severe falciparum malaria and, more specifically, with severe malarial anaemia, one of the most prevalent malaria complications
	rs1801274 in FCGR2A highly associated to Kawasaki disease
	genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS