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FLASH GENE
Symbol FCGR2A contributors: mct - updated : 21-06-2017
HGNC name Fc fragment of IgG, low affinity IIa, receptor (CD32)
HGNC id 3616
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • single chain transmembrane (TM) protein
  • two Ig extracellular domains
  • a cytoplasmic tail with the immunoreceptor tyrosine based inhibitory motifs (ITIM)
    • mono polymer hexamer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • binding to the Fc region of immunoglobulins gamma
  • playing a role in the potentiation of platelet activation induced by weak stimulation
  • FCGR2A engagement of tissue soluble immune complexes generates NETs (neutrophil extracellular traps), a proinflammatory process linked to autoimmunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GZMB is an important mediator of FCGR2A function in human monocytes
    • cell & other
    REGULATION
    activated by in platelets downstream G-protein-coupled receptors (may be a novel general mechanism for the reinforcement of platelet activation induced by low concentrations of agonists) (Canobbio 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to glomerulonephritis in Caucasoid patients with lupus erythematosus
  • to acute coronary syndromes (ACS)
  • to severe falciparum malaria
  • to Kawasaki disease
  • to Takayasu arteritis
    • Variant & Polymorphism SNP
  • Fc gamma RIIa-H/R131, over-represented
  • association of the R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease
  • FCGR2a131RR positively associated with severe falciparum malaria and, more specifically, with severe malarial anaemia, one of the most prevalent malaria complications
  • rs1801274 in FCGR2A highly associated to Kawasaki disease
  • genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS