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FLASH GENE

Symbol

FCGR2A

contributors: mct - updated : 21-06-2017

HGNC name	Fc fragment of IgG, low affinity IIa, receptor (CD32)
HGNC id	3616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.16 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001136219 7 - 2429 NP_001129691 - 317 - - NM_021642 7 - 2426 NP_067674 - 316 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective bone subchondral     Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Blood/Hematopoietic monocyte Blood/Hematopoietic platelet Respiratory alveolar macrophage

cell lineage	primarily, by cells of the myeloid lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	single chain transmembrane (TM) protein
	two Ig extracellular domains
	a cytoplasmic tail with the immunoreceptor tyrosine based inhibitory motifs (ITIM)

mono polymer

hexamer

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	binding to the Fc region of immunoglobulins gamma
	playing a role in the potentiation of platelet activation induced by weak stimulation
	FCGR2A engagement of tissue soluble immune complexes generates NETs (neutrophil extracellular traps), a proinflammatory process linked to autoimmunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GZMB is an important mediator of FCGR2A function in human monocytes

cell & other

REGULATION

activated by

in platelets downstream G-protein-coupled receptors (may be a novel general mechanism for the reinforcement of platelet activation induced by low concentrations of agonists) (Canobbio 2006)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to glomerulonephritis in Caucasoid patients with lupus erythematosus to acute coronary syndromes (ACS) to severe falciparum malaria to Kawasaki disease to Takayasu arteritis

Variant & Polymorphism SNP	Fc gamma RIIa-H/R131, over-represented
	association of the R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease
	FCGR2a131RR positively associated with severe falciparum malaria and, more specifically, with severe malarial anaemia, one of the most prevalent malaria complications
	rs1801274 in FCGR2A highly associated to Kawasaki disease
	genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS