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FLASH GENE
Symbol FCGR2A contributors: mct - updated : 21-06-2017
HGNC name Fc fragment of IgG, low affinity IIa, receptor (CD32)
HGNC id 3616
Location 1q23.3      Physical location : 161.475.204 - 161.489.359
Synonym name
  • cell differentiation antigen CD32 (gp40), 40kD,low affinity Fc gamma RII-IgG receptor, identified by monoclonal antibodies 2E1, CIKM5 (see IGFCR@)
  • immunoglobulin G Fc receptor II
  • CD32 antigen
  • Synonym symbol(s) CD32, FCG2, FCG2A, FCR2, IGFR2, FCGR2A1, CD32A, CDw32, Fc-gamma-RIIa, MGC23887, MGC30032
    DNA
    TYPE functioning gene
    STRUCTURE 14.16 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2429 - 317 - -
    7 - 2426 - 316 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebonesubchondral  
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticplatelet
    Respiratoryalveolar macrophage
    cell lineage primarily, by cells of the myeloid lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • single chain transmembrane (TM) protein
  • two Ig extracellular domains
  • a cytoplasmic tail with the immunoreceptor tyrosine based inhibitory motifs (ITIM)
  • mono polymer hexamer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • binding to the Fc region of immunoglobulins gamma
  • playing a role in the potentiation of platelet activation induced by weak stimulation
  • FCGR2A engagement of tissue soluble immune complexes generates NETs (neutrophil extracellular traps), a proinflammatory process linked to autoimmunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GZMB is an important mediator of FCGR2A function in human monocytes
  • cell & other
    REGULATION
    activated by in platelets downstream G-protein-coupled receptors (may be a novel general mechanism for the reinforcement of platelet activation induced by low concentrations of agonists) (Canobbio 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to glomerulonephritis in Caucasoid patients with lupus erythematosus
  • to acute coronary syndromes (ACS)
  • to severe falciparum malaria
  • to Kawasaki disease
  • to Takayasu arteritis
  • Variant & Polymorphism SNP
  • Fc gamma RIIa-H/R131, over-represented
  • association of the R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease
  • FCGR2a131RR positively associated with severe falciparum malaria and, more specifically, with severe malarial anaemia, one of the most prevalent malaria complications
  • rs1801274 in FCGR2A highly associated to Kawasaki disease
  • genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS