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FLASH GENE
Symbol SLC2A12 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2 (facilitated glucose transporter), member 12
HGNC id 18067
Location 6q23.2      Physical location : 134.308.718 - 134.373.789
Synonym symbol(s) GLUT8, GLUT12
DNA
TYPE functioning gene
STRUCTURE 65.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5572 - 617 - 2014 24820014
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine    Homo sapiens
Nervousbraindiencephalonamygdala moderately
 brainlimbic systemhippocampus moderately
Reproductivemale systemtestis  highly
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Epithelialsecretoryglandularendocrine 
Muscularsmoothvessel   Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SLC2A8 and SLC2A12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their N- terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • sugar transporter family, glucose transporter subfamily
  • facilitative family of glucose transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    text
  • is located in the apical cytoplasm, below the brush border membrane, and in the perinuclear region of human enterocytes
  • basic FUNCTION
  • insulin-regulated facilitative sugar transporter
  • dispensable for embryonic development but influences hippocampal neurogenesis and heart function
  • in contrast to SLC2A4, insulin does not mediate SLC2A12 translocation, which may function as a basal GLUT located primarily at the cell surface in the myocardium
  • evidence for SLC2A9 and SLC2A12 expression in vascular smooth muscle cells (VSMCs) in conjunction with the previously identified SLC2A1 and SLC2A10
  • SLC2A12 activity is voltage dependent
  • plays a critical role in the model of breast cancer progression through high glucose concentrations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC2A8 regulates enterocyte fructose transport by regulating SLC2A12, and disrupted SLC2A8 function has deleterious long-term metabolic sequelae
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS