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FLASH GENE

Symbol

SLC26A11

contributors: np/ - updated : 15-11-2005

HGNC name	solute carrier family 26, member 11
HGNC id	14471

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	33.06 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001166347 18 - 2930 NP_001159819 - 606 - - NM_173626 18 - 2927 NP_775897 - 606 - - NM_001166349 17 - 2730 NP_001159821 - 606 - - NM_001166348 17 - 2860 NP_001159820 - 606 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Urinary kidney       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	made of a N and C cytoplasmic termini:
	twelve transmembrane segments (12TM)
	a large cytoplasmic tail
	a sulfate transporter motif
	a relatively hydrophobic region near the C terminus
	the STAS domain (sulfate transporter and anti-sigma factor antagonist)

HOMOLOGY

Homologene

FAMILY	anion exchanger family
	SLC26A/SulP transporter (TC 2.A.53) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

basic FUNCTION

anion exchanger, Na+ independent

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SLC26A2 to mediate DIDs-sensitive sulfate uptake in HEVEC (high endothelial venuls, endothelial cells)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS