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FLASH GENE
Symbol SLC24A2 contributors: mct/npt - updated : 10-09-2009
HGNC name solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
HGNC id 10976
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sets of hydrophobic transmembrane segments each with a alpha repeat through to form the ion binding pocket for transport, separated by a large cytosolic loop
  • twelve transmembrane segments
    • conjugated GlycoP
    isoforms Precursor 58 aa signal peptide
    HOMOLOGY
    interspecies homolog to rattus Slc24a2 (89.7 pc)
    homolog to murine Slc24a2 (90.2 pc)
    intraspecies homolog to SLC24A1
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness
  • playing a key role in the process of light adaptation
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors (Kinjo 2003)
  • playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone (Dong 2006)
  • probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration (Lytton 2007)
  • bidirectional transporters normally extruding Ca(2+) from the cell (forward exchange), but also able to carry Ca(2+) into the cell (reverse exchange) when the transmembrane Na(+) gradient is reversed (Schnetkamp 2004)
  • implicated in a regulatory kinetic state of Ca2+ transport that may play a prominent role in regulation of Ca2+ extrusion in cellular environments such as neuronal synapses that experience frequent and dynamic Ca2+ fluxes (Altimimi 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transports (antiport) a Ca(2+) and a K(+) in exchange for four Na(+)
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • K+
  • Na+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS