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FLASH GENE

Symbol

SLC24A2

contributors: mct/npt - updated : 10-09-2009

HGNC name	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
HGNC id	10976

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9p22.1      Physical location : 19.507.450 - 19.788.591
Synonym name	Na(+)/K(+)/Ca(2+)-exchange protein 2
	retinal cone Na-Ca+K exchanger
Synonym symbol(s)	NCKX2

DNA

TYPE	functioning gene
STRUCTURE	270.95 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020344 10 - 2221 NP_065077 - 661 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       lowly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth vessel

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Visual cone photoreceptor Visual ganglion cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two sets of hydrophobic transmembrane segments each with a alpha repeat through to form the ion binding pocket for transport, separated by a large cytosolic loop
	twelve transmembrane segments

conjugated

GlycoP

isoforms

Precursor

58 aa signal peptide

HOMOLOGY

interspecies	homolog to rattus Slc24a2 (89.7 pc)
	homolog to murine Slc24a2 (90.2 pc)

intraspecies

homolog to SLC24A1

Homologene

FAMILY	sodium/potassium/calcium exchanger family
	SLC24A subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	acting as a critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness
	playing a key role in the process of light adaptation
	polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors (Kinjo 2003)
	playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone (Dong 2006)
	probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration (Lytton 2007)
	bidirectional transporters normally extruding Ca(2+) from the cell (forward exchange), but also able to carry Ca(2+) into the cell (reverse exchange) when the transmembrane Na(+) gradient is reversed (Schnetkamp 2004)
	implicated in a regulatory kinetic state of Ca2+ transport that may play a prominent role in regulation of Ca2+ extrusion in cellular environments such as neuronal synapses that experience frequent and dynamic Ca2+ fluxes (Altimimi 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	transports (antiport) a Ca(2+) and a K(+) in exchange for four Na(+)

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+
	K+
	Na+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS