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FLASH GENE

Symbol

SLC22A11

contributors: mct/npt - updated : 13-04-2010

HGNC name	solute carrier family 22 (organic anion/cation transporter), member 11
HGNC id	18120

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.1      Physical location : 64.323.097 - 64.338.998
Synonym name	solute carrier family 22 member 11
Synonym symbol(s)	OAT4, MGC34282

DNA

TYPE	functioning gene
STRUCTURE	15.90 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018484 10 - 2545 NP_060954 - 550 - Kimura 2002)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney tubule convoluted tubule proximal tubule

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane domains (12TM)
	cytoplasmic N and C termini
	one nucleotide (ATP/GTP) binding site motif

HOMOLOGY

Homologene

FAMILY	major facilitator superfamily
	organic cation transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	located at the apical membrane of proximal tubule cells (Hagos 2007)

basic FUNCTION	mediating organic transport
	transport of various cephalosporines, tetracyclines, prostaglandins
	involved in renal secretion and reabsorption of endogenous substances as well as many drugs and xenobiotics (Hagos 2007)
	play crucial roles in the renal secretion of various drugs (Ogasawara 2008)
	long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia (Hagos 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction of PDZ proteins with SLC22A11, that may be cell-specific (in placenta, a different set of interacting proteins from PDZK1 and SLC9A3R1 may be required to modulate its activity) (Zhou 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	could be used as markers for certain diseases including osteoporosis (Lee 2008)
Marker
Therapy target

ANIMAL & CELL MODELS