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FLASH GENE

Symbol

SLCO1C1

contributors: mct - updated : 15-09-2021

HGNC name	solute carrier organic anion transporter family, member 1C1
HGNC id	13819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p12.2      Physical location : 20.848.288 - 20.906.318
Synonym name	solute carrier family 21 (organic anion transporter), member 14
	organic anion transporting polypeptide 14
	organic anion transporter polypeptide-related protein 5
	organic anion transporter F
Synonym symbol(s)	OATP-F, SLC21A14, OATP1, OATP1C1, OAT-RP-5, OATP14, OATPRP5

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with OATP-A, OATP-C, OATP8
STRUCTURE	71.59 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017435 15 - 3498 NP_059131 - 712 - 2005 15652527 isoform 2 NM_001145946 16 - 3478 NP_001139418 - 730 - 2005 15652527 isoform 1 NM_001145945 15 - 3228 NP_001139417 - 663 - 2005 15652527 isoform 3 NM_001145944 13 - 3305 NP_001139416 - 612 - 2005 15652527 isoform 4

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Nervous brain diencephalon hypothalamus     Reproductive male system testis

cells

System Cell Pubmed Species Stage Rna symbol Reproductive Leydig cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one Kazal-like domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Slco1c1 (84.1pc)
	homolog to rattus Slco1c1 (84.8pc)

Homologene

FAMILY

organic anion transporter family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing an important role in the disposition of thyroid hormones in brain and testis
	transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues
	can transport fenamates (non steroidal antiinflammatory drugs) into brain barrier cells (Westholm 2009)
	high affinity for thyroxine, tri-iodothyronine and reverse tri-iodothyronine
	SLCO1C1 protein transports thyroid hormone into astrocytes from blood
	unique gate-keeper function of SLC16A2 and SLCO1C1 in satellite cells (SCs) activation, underscoring the importance of a finely tuned TH signaling during myogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	transport ions

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

may function as a pair with SLC16A2 to transport T4 from the blood into the cerebrospinal fluid and to efflux thyroid hormones to their inatives metabolites from the cerebral spinal fluid to blood (Roberts 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to hippocampal sclerosis of aging

Variant & Polymorphism	polymorphism of the gene may be associated with fatigue and depression in patients suffering from hypothyroidism (Van der Deure 2008)
	rs73069071 risk genotype was associated with hippocampal sclerosis (HS) pathology

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS