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FLASH GENE

Symbol

SLC16A6

contributors: npt/mct - updated : 06-01-2017

HGNC name	solute carrier family 16, member 6 (monocarboxylic acid transporter 7)
HGNC id	10927

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004694 6 - 2689 NP_004685 - 523 - Halestrap (1999)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium hair cell receptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	comprising twelve transmembrane spanning segments
	a cytoplasmic loop between TM6 and TM7

HOMOLOGY

Homologene

FAMILY	major facilitator superfamily
	monocarboxylate porter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derivedfrom leucine, valine and isoleucine
	involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor (Tondreau 2008)
	CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	monocarboxylate transport

PATHWAY

metabolism

monocarbon

signaling

a component

INTERACTION

DNA

RNA

small molecule
	proton linked

protein

CD147

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS