Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC16A6 contributors: npt/mct - updated : 06-01-2017
HGNC name solute carrier family 16, member 6 (monocarboxylic acid transporter 7)
HGNC id 10927
Location 17q24.2      Physical location : 66.263.167 - 66.287.405
Synonym name
  • solute carrier family 16 (monocarboxylic acid transporters), member 6
  • monocarboxylate transporter 6
    • Synonym symbol(s) MCT6, MCT7
    DNA
    TYPE functioning gene
    STRUCTURE 23.07 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2689 - 523 - Halestrap (1999)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • comprising twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derivedfrom leucine, valine and isoleucine
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor (Tondreau 2008)
  • CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
    • protein
  • CD147
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS