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FLASH GENE
Symbol SLC16A5 contributors: mct/npt - updated : 18-11-2009
HGNC name solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
HGNC id 10926
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • comprising twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • five short overlapping upstream openreading frames
  • truncated C-terminus (Halestrap 1999)
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine
  • involved in the transport of various drugs such as probenecid and nateglinide (Murakami 2005)
  • may be involved in the disposition of various drugs, including bumetanide (Murakami 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
    • protein
  • CD147
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS