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FLASH GENE
Symbol SLC16A5 contributors: mct/npt - updated : 18-11-2009
HGNC name solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
HGNC id 10926
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • comprising twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • five short overlapping upstream openreading frames
  • truncated C-terminus (Halestrap 1999)
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine
  • involved in the transport of various drugs such as probenecid and nateglinide (Murakami 2005)
  • may be involved in the disposition of various drugs, including bumetanide (Murakami 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
    • protein
  • CD147
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS