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FLASH GENE

Symbol

SLC16A5

contributors: mct/npt - updated : 18-11-2009

HGNC name	solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
HGNC id	10926

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	18.19 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   ALU
text structure	an Alu insertion event in the 3 prime UTR (Halestrap 1999)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004695 7 - 1940 NP_004686 - 505 - Halestrap (2004)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	comprising twelve transmembrane spanning segments
	a cytoplasmic loop between TM6 and TM7
	five short overlapping upstream openreading frames
	truncated C-terminus (Halestrap 1999)

HOMOLOGY

Homologene

FAMILY	major facilitator superfamily
	monocarboxylate porter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

basic FUNCTION	catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine
	involved in the transport of various drugs such as probenecid and nateglinide (Murakami 2005)
	may be involved in the disposition of various drugs, including bumetanide (Murakami 2005)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	monocarboxylate transport

PATHWAY

metabolism

monocarbon

signaling

a component

INTERACTION

DNA

RNA

small molecule
	proton linked

protein

CD147

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS