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FLASH GENE
Symbol SLC16A5 contributors: mct/npt - updated : 18-11-2009
HGNC name solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
HGNC id 10926
Location 17q25.1      Physical location : 73.084.054 - 73.102.246
Synonym name
  • solute carrier family 16 (monocarboxylic acid transporters), member 5
  • monocarboxylate transporter 5
    • Synonym symbol(s) MCT5
    DNA
    TYPE functioning gene
    STRUCTURE 18.19 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU
    text structure an Alu insertion event in the 3 prime UTR (Halestrap 1999)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1940 - 505 - Halestrap (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • comprising twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • five short overlapping upstream openreading frames
  • truncated C-terminus (Halestrap 1999)
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine
  • involved in the transport of various drugs such as probenecid and nateglinide (Murakami 2005)
  • may be involved in the disposition of various drugs, including bumetanide (Murakami 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
    • protein
  • CD147
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS