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FLASH GENE
Symbol SKIL contributors: mct - updated : 08-03-2019
HGNC name SKI-like oncogene
HGNC id 10897
Location 3q26.2      Physical location : 170.075.472 - 170.110.948
Synonym name
  • SKI-related novel gene
  • ski-related oncogene snoN
  • Synonym symbol(s) SNO, SNOA, SNON, SnoI,
    DNA
    TYPE functioning gene
    STRUCTURE 39.17 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2870 - 415 widely 2016 27430247
    - splicing 3490 - 387 only skeletal muscle 2016 27430247
    7 - 7202 - 684 - 2016 27430247
  • SNON
  • 8 - 6711 - 664 - 2016 27430247
    7 - 7199 - 684 - 2016 27430247
    6 - 7061 - 638 only the smaller SnoN isoform, SNON2, is produced in the testis (germ cells production was highly regulated, being detected only in gonocytes and interstitial cells at birth and in pachytene spermatocytes at puberty) 2009 19526521
  • SNON2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Endocrineneuroendocrinepituitary  moderately
    Lymphoid/Immunelymph node   predominantly
    Nervousbrain   lowly
    Respiratorylung   highly
     respiratory tracttrachea  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  moderately
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated Other
    mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Skil (89.7 pc)
    homolog to murine Skil (89 pc)
    Homologene
    FAMILY
  • SKI family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a regulatory role in cell division or differentiation in response to extracellular signal
  • acting as a transcription corepressor
  • having a transforming growth factor beta receptor, cytoplasmic mediator activity
  • promoting the assembly of a protein complex containing SKIL, ING2, and SMAD2
  • novel Smad-independent pathway of SKIL function that mediates its anti-oncogenic activity
  • plays an important role in embryonic development, tumorigenesis and aging
  • mediates a negative feedback mechanism evoked by TGFB1 to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes
  • negative regulator of TGFB1 signaling, coordinates TGFB1 and prolactin signaling to control alveologenesis and lactogenesis
  • potential role for the PIAS1-SKIL sumoylation pathway in controlling breast cancer metastasis
  • regulates multiple signaling pathways in a tissue- and developmental stage-dependent manner and has broad functions in embryonic angiogenesis, mammary gland alveologenesis, cancer, and aging
  • plays an important role in adipocyte differentiation and WAT development by decreasing activity in the activin/SMAD2 signaling pathway
  • CELLULAR PROCESS cell cycle, division
    cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forming a complex with ING2 and SMAD2
  • forms a stable complex with the R-SMAD (SMAD3) and the Co-SMAD (SMAD4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SMAD2 and SMAD3
  • interacting with ING2
  • plays likely a role in regulating ADAM12 expression in response to TGFB1
  • elevated SKIL promotes STAT5B signaling by enhancing its stability, thereby sharply increasing the activity of prolactin signaling at the onset of lactation
  • NFATC1 sequestering the SMAD3 prevents the proteasome mediated degradation of SKIL and SKIL has a role on the regulation of MMP2, MMP9 activity
  • protein ubiquitination promotes megakaryopoiesis via degrading SKIL, an inhibitor of ITGB3 expression, strengths the roles of ubiquitination in cellular differentiation
  • MAD2L2 has a profibrotic role during fibroblast activation and tubulointerstitial fibrosis (TIF) by suppressing SKIL expression
  • cell & other
    REGULATION
    Other sumoylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinoma in progression
    constitutional     --over  
    renal SKIL upregulation ameliorates renal fibrosis by relieving high glucose-induced epithelial-mesenchymal transition (EMT) (pMID: 28350874)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    might serve as a potential therapeutic target for pancreatic cancer
    ANIMAL & CELL MODELS