basic FUNCTION
| playing a regulatory role in cell division or differentiation in response to extracellular signal |
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acting as a transcription corepressor |
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having a transforming growth factor beta receptor, cytoplasmic mediator activity |
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promoting the assembly of a protein complex containing SKIL, ING2, and SMAD2 |
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novel Smad-independent pathway of SKIL function that mediates its anti-oncogenic activity |
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plays an important role in embryonic development, tumorigenesis and aging |
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mediates a negative feedback mechanism evoked by TGFB1 to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes |
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negative regulator of TGFB1 signaling, coordinates TGFB1 and prolactin signaling to control alveologenesis and lactogenesis |
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potential role for the PIAS1-SKIL sumoylation pathway in controlling breast cancer metastasis |
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regulates multiple signaling pathways in a tissue- and developmental stage-dependent manner and has broad functions in embryonic angiogenesis, mammary gland alveologenesis, cancer, and aging |
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plays an important role in adipocyte differentiation and WAT development by decreasing activity in the activin/SMAD2 signaling pathway |