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FLASH GENE
Symbol SH2D3C contributors: mct - updated : 01-02-2008
HGNC name SH2 domain containing 3C
HGNC id 16884
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   moderately
Lymphoid/Immunelymph node   moderately
 spleen   highly
 thymus   predominantly
 tonsils   moderately
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a guanine nucleotide exchange factor-like (Ras-GEF) domain
  • a SH2 domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Sh2d3c (87.2 pc)
    homolog to murine Sh2d3c (87 pc)
    Homologene
    FAMILY
  • member of a family of cytoplasmic proteins involved in cell adhesion/migration and antiestrogen resistance
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • associated with the membrane when EGF-stimulated
  • found at ruffling membranes
    • basic FUNCTION
  • acting as a SH3/SH2 adaptor
  • acting as a guanyl-nucleotide exchange factor
  • adaptor protein required for marginal zone B-cell maturation
  • functions in concert with the scaffolding protein NEDD9, because with NEDD9 are constitutively associated in B cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
  • small GTPase mediated signal transduction
    • a component
  • integral component of the signaling networks coordinating marginal zone B-cell adhesion and migration
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTK2B
  • constitutively bound to NEDD9 in B cells and this association is required for NEDD9 serine/threonine phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS