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FLASH GENE
Symbol SH2D3C contributors: mct - updated : 01-02-2008
HGNC name SH2 domain containing 3C
HGNC id 16884
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 2164 77 703 widely Vervoort, 2007
  • interacting with BCAR1/CAS and NEDD9/HEF1
  • initial ATG in exon 3
    • 12 splicing 3114 94 860 widely Vervoort, 2007
  • initial ATG in exon 1
    • 10 splicing - - 702 widely Vervoort, 2007
  • initial ATG in exon 6
    • 12 splicing - - 792 - Vervoort, 2007
  • initial ATG in exon 4
    		•
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   moderately
    Lymphoid/Immunelymph node   moderately
     spleen   highly
     thymus   predominantly
     tonsils   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a guanine nucleotide exchange factor-like (Ras-GEF) domain
  • a SH2 domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Sh2d3c (87.2 pc)
    homolog to murine Sh2d3c (87 pc)
    Homologene
    FAMILY
  • member of a family of cytoplasmic proteins involved in cell adhesion/migration and antiestrogen resistance
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • associated with the membrane when EGF-stimulated
  • found at ruffling membranes
    • basic FUNCTION
  • acting as a SH3/SH2 adaptor
  • acting as a guanyl-nucleotide exchange factor
  • adaptor protein required for marginal zone B-cell maturation
  • functions in concert with the scaffolding protein NEDD9, because with NEDD9 are constitutively associated in B cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
  • small GTPase mediated signal transduction
    • a component
  • integral component of the signaling networks coordinating marginal zone B-cell adhesion and migration
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTK2B
  • constitutively bound to NEDD9 in B cells and this association is required for NEDD9 serine/threonine phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS