Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SH2D3C

contributors: mct - updated : 01-02-2008

HGNC name	SH2 domain containing 3C
HGNC id	16884

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	41.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant beta 11 splicing 2164 77 703 widely Vervoort, 2007 interacting with BCAR1/CAS and NEDD9/HEF1 initial ATG in exon 3 variant alpha 12 splicing 3114 94 860 widely Vervoort, 2007 initial ATG in exon 1 variant gamma 10 splicing - - 702 widely Vervoort, 2007 initial ATG in exon 6 variant delta 12 splicing - - 792 - Vervoort, 2007 initial ATG in exon 4

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately   vessel       moderately Lymphoid/Immune lymph node       moderately   spleen       highly   thymus       predominantly   tonsils       moderately

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a guanine nucleotide exchange factor-like (Ras-GEF) domain
	a SH2 domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Sh2d3c (87.2 pc)
	homolog to murine Sh2d3c (87 pc)

Homologene

FAMILY

member of a family of cytoplasmic proteins involved in cell adhesion/migration and antiestrogen resistance

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	associated with the membrane when EGF-stimulated
	found at ruffling membranes

basic FUNCTION	acting as a SH3/SH2 adaptor
	acting as a guanyl-nucleotide exchange factor
	adaptor protein required for marginal zone B-cell maturation
	functions in concert with the scaffolding protein NEDD9, because with NEDD9 are constitutively associated in B cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

	JNK cascade
	small GTPase mediated signal transduction

a component

integral component of the signaling networks coordinating marginal zone B-cell adhesion and migration

INTERACTION

DNA

RNA

small molecule

protein	interacting with PTK2B
	constitutively bound to NEDD9 in B cells and this association is required for NEDD9 serine/threonine phosphorylation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS