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FLASH GENE

Symbol

IAPP

contributors: mct - updated : 12-10-2016

HGNC name	islet amyloid polypeptide
HGNC id	5329

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   basal IAPP secretion is higher in T2DM and impaired glucose tolerance versus normal glucose tolerance but is reduced in response to hyperglycemia and arginine constitutional     --over   in young with new-onset of type 1 diabetes mellitus constitutional     --over   in women with polycystic ovary syndrome

Susceptibility

for NIDDM12 (in japanese)

Variant & Polymorphism other	mutation S2OG, inducing aggregation in the islet extracellular space to form amyloid deposits

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS