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FLASH GENE

Symbol

SDCBP2

contributors: np - updated : 03-01-2007

HGNC name	syndecan binding protein (syntenin) 2
HGNC id	15756

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001199784 - - 1484 NP_001186713 - 292 - - NM_080489 9 - 1595 NP_536737 - 292 - - NM_015685 5 - 1375 NP_056500 - 207 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two PDZ (PSD95,Dlg,Z0-1/2) motifs

mono polymer

homomer , monomer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome
	intracellular,cytoplasm,cytoskeleton,microfilament
	intracellular,nucleus

basic FUNCTION	regulation of plasma membrane dynamics
	potential role in nuclear processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of adherens junctions with syndecans 1,E-cadherin,beta and alpha-catenins
	forming homodimers and heterodimers with SDCBP

INTERACTION

DNA

RNA

small molecule

protein	associating with the cytoplasmic tail of ILR5R alpha
	interacting with the FYA motif of syndecan
	interacting with the cytoplasmic tail of neurofascin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS