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FLASH GENE

Symbol

SDC3

contributors: mct - updated : 26 -08 -20

HGNC name	syndecan 3 (N-syndecan)
HGNC id	10660

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta       Digestive intestine large intestine colon       stomach         Endocrine adrenal gland         Lymphoid/Immune spleen         Nervous brain basal nuclei striatum   highly Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular domain with eight glycosaminoglycan attachment sites arranged in two clusters
	an intracellular domain with a PDZ domain-interacting motif and four conserved tyrosine residues

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	playing a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent
	regulator of the mitotic behavior of chondrocytes
	may be involving formation of dimeric/oligomeric structures on their cell surface
	with SDC4,function as coreceptors for tyrosine kinases and in cell adhesion
	novel regulator of feeding behavior and body weight, having a potential role as a modulator of gonadal steroid function
	Syndecan-3 and NOTCH1 cooperate in regulating homeostasis of the satellite cell population and myofiber size
	may directly transduce GDNF family ligands (GFLs) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET

CELLULAR PROCESS	cell life
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with NOTCH1 and is required for NOTCH1 processing by ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and signal transduction
	GDNF family ligands (GFLs)-syndecan-3 interaction mediates both cell spreading and neurite outgrowth with the involvement of Src kinase activation

cell & other	major HIV-1 attachment receptor on dendritic cells (DC) (is a DC-specific heparan sulfate (HS) proteoglycan that captures HIV-1 through interaction with the HIV-1 envelope glycoprotein gp120) (

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	high expression of MDK and SDC3 may contribute to the highly perineural invasion and poor prognosis of human pancreatic cancer
Therapy target
	System Type Disorder Pubmed immunology immunodeficiency   an effective microbicide should target both syndecan-3 and CD209 on dendritic cells to prevent HIV transmission

ANIMAL & CELL MODELS

Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells