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FLASH GENE

Symbol

SCGN

contributors: mlc - updated : 23-11-2007

HGNC name	secretagogin, EF-hand calcium binding protein
HGNC id	16941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	anonymous DNA segment
SPECIAL FEATURE	opposite orientation
STRUCTURE	49.00 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter sequence showed subtle but significant regulation by glucose within the normo-physiological range

MAPPING

cloned

linked

status

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 11 - 1492 - 276 in pancreas, in the central nervous system and organs containing neurendocrine cells Skovhus (2006) secretagogin-R22 - - - - - in pancreas, in the central nervous system and organs containing neurendocrine cells Zierhut (2005) one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing setagin - - 705 - 49 only in pancreas Zierhut (2005) due to a frame shift, only the first 27 amino acids are identical to secretagogin

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine neuroendocrine pituitary         pancreas         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)   highly

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	calcium-binding protein
	may be involved in KCL-stimulated calcium flux and cell proliferation
	being novel marker for neuroendocrine differentiation.

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in serum after ischemic neuronal damage tumoral     --over   in the cytosol and the nucleus of well-differentiated neuroendocrine carcinoids and carcinoid metastases, as well as in neuroendocrine tumors from the lung, pancreas and adrenal gland

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS