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FLASH GENE
Symbol SCARA3 contributors: mct/npt - updated : 31-07-2004
HGNC name scavenger receptor class A, member 3
HGNC id 19000
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a membrane-spanning
  • an alpha-helix coiled-coil domain
  • a collagen-like domain
  • C terminus binds with cleavage and polyadenylation-specific factor 3 (CPSF3), an enzyme necessary for polyadenylation of RNA (Zhu 2009)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text primarily in the cytoplasm near the cell membrane (Zhu 2009)
    basic FUNCTION
  • may be a potent tumor sup-pressor gene (Yu 2006)
  • undergoes hypermethylation in over 30 p100 of prostate cancers (Zhu (2009)
  • probably has a role beyond a cell stress-response gene (Zhu 2009)
  • induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme (Zhu 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CPSF3 (induced redistribution of CPSF3 from the nucleus to the cytoplasm)(Zhu 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer with associated with a high rate of prostate cancer metastasis(Yu 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS