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FLASH GENE
Symbol RPS6KA4 contributors: np/ - updated : 04-07-2007
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 4
HGNC id 10433
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two protein kinase domains
  • one N terminal,the other C like, calcium-calmodulin like at C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • ribosdomal protein S6 kinase(RSK) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated in the activation of the mitogen- activated kinase cascade
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for p38 alpha MAPK phosphorylating cAMP response element binding protein CREB and c Fos peptides
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS