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FLASH GENE

Symbol

HPX

contributors: - updated : 14-06-2006

HGNC name	hemopexin
HGNC id	5171

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one high affinity binding site for heme
	five hemopexin-like domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Hpx
	ortholog to murine Hpxn

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	transporting heme to hepatocytes for iron salvage
	binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

homeostasis , extracellular transport

text	iron ion homeostasis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, other,
	Fe2+
	heme

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS