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FLASH GENE
Symbol HPX contributors: - updated : 14-06-2006
HGNC name hemopexin
HGNC id 5171
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
Lymphoid/Immunespleen   moderately
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one high affinity binding site for heme
  • five hemopexin-like domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Hpx
    ortholog to murine Hpxn
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • transporting heme to hepatocytes for iron salvage
  • binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS homeostasis , extracellular transport
    text
  • iron ion homeostasis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Fe2+
  • heme
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS