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FLASH GENE
Symbol HPX contributors: - updated : 14-06-2006
HGNC name hemopexin
HGNC id 5171
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
Lymphoid/Immunespleen   moderately
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one high affinity binding site for heme
  • five hemopexin-like domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Hpx
    ortholog to murine Hpxn
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • transporting heme to hepatocytes for iron salvage
  • binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS homeostasis , extracellular transport
    text
  • iron ion homeostasis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Fe2+
  • heme
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS