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FLASH GENE
Symbol RBM38 contributors: mct/pgu - updated : 06-06-2015
HGNC name RNA binding motif protein 38
HGNC id 15818
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RRM domain required for binding, and regulating the stability of, TP63 transcript
    • HOMOLOGY
    interspecies homolog to murine Rbm38 (95.4pc)
    homolog to rattus Rbm38 (94.9pc)
    Homologene
    FAMILY
  • RBM38 family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • RNA-binding protein and target of the TP53 family, required for maintaining the stability of the basal and stress-induced CDKN1A transcript
  • RNA-binding protein and a target of the TP53 family, regulating TP63 mRNA stability and consequently TP63 activity
  • modulates the RNA binding activity of ELAVL1 and cooperates with it to regulate CDKN1A mRNA stability
  • promotes keratinocyte differentiation by repressing TP63 expression
  • plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
  • plays potentially a role in tumorigenesis by repressing TP53 translation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA can bind AU-rich elements in CDKN1A 3'UTR
    small molecule
    protein
  • plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
  • TP53 target and a RNA-binding protein, that is a critical regulator of TP53 translation
  • ELAVL1 is a target of RBM38 and a mediator of RBM38-induced growth suppression and facilitates RBM38-mediated growth suppression by repressing MYC expression
  • RBM38 is a target of TP73, the mutual regulation between TP73 and RBM38 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional TP53
  • GDF15 can be regulated through RBM38 via mRNA stability
  • ERBB2, MYC, WIF1, RBM38, PTEN, are involved in the HOTAIR regulation network
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    led to significant G&8320;/G&8321; cell cycle accumulation and significantly enhanced cellular resistance to radiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a potential therapeutic target for enhancing tumor sensitivity to radiation
    ANIMAL & CELL MODELS