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FLASH GENE

Symbol

RIT1

contributors: mct/npt - updated : 17-09-2013

HGNC name	Ras-like without CAAX 1
HGNC id	10023

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	13.59 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001256821 6 - 3425 25 219 - Shi (2005) NM_001256820 5 - 3306 NP_001243749 - 183 - - NM_006912 6 - 3455 NP_008843 - 219 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Nervous brain         Homo sapiens Fetal   brain       highly Homo sapiens Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

highly conserved G3 and G4 domains of RAS proteins

HOMOLOGY

Homologene

FAMILY

Ras subfamily of small guanine triphosphatases (GTPases)

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may play important roles in the regulation of signaling pathways and cellular processes distinct from those controlled by Ras
	implicated in a novel pathway of neuronal development and regeneration by coupling specific trophic factor signals to sustained activation of the B-Raf/ERK and p38 MAP kinase cascades
	plays a key role in human neuronal development and regeneration through activating both known and as yet undefined signaling pathways
	differentially regulates axonal and dendritic growth
	may be involved in the signaling pathway for Goalpha-mediated neuronal differentiation
	role for RIT1 in injury-induced neurogenesis, functioning as a selective survival mechanism for immature hippocampal neurons within the subgranular zone of the dentate gyrus following traumatic brain injury (TBI)
	critical role for the RIT1-MAPK14 signaling cascade in promoting hippocampal neuron survival following oxidative stress

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	central regulator of MAPK14-dependent signaling cascade that functions as a critical cellular survival mechanism in response to stress
	LZTR1 is a RIT1 interactor, that acts as an adaptor for protein degradation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NS8

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Rit1-null mice have been shown to grow to adulthood without any apparent abnormalities