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FLASH GENE
Symbol RIMS2 contributors: mct - updated : 01-09-2020
HGNC name regulating synaptic membrane exocytosis 2
HGNC id 17283
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal zinc finger, ligand of 14-3-3 proteins, binding to RAB3 as a function of GTP
  • two C-terminal C2 domain, rabphilin-3A effector domain
  • a central PDZ domain
  • three C terminal SAM domains
    • HOMOLOGY
    interspecies homolog to murine Rabphilin 3A
    intraspecies homolog to RIMS1
    Homologene
    FAMILY RIM family of active zone proteins
    CATEGORY chaperone/stress , regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    text
  • synaptic
  • mitochondrial carrier protein
    • basic FUNCTION
  • integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitters release
  • regulating vesicle exocytosis during short-term plasticity
  • RIMS1 and RIMS2 are multidomain active zone proteins of presynaptic terminals
  • RIMS1 and RIMS2 are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis
  • component of the presynaptic active zone and modulator of exocytosis
  • piccolo, RIMS2, RIMS3, are involved in the neurobiology of schizophrenia
  • determines docking and priming states in insulin granule exocytosis
  • RIMS1, and RIMS2 co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic CaČ+ channel density and vesicle docking at the presynaptic active zone
  • mediate pyrimidine exchange in and out of vesicles
  • is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization
  • plays an important role in maintaining the normal synaptic connection at the ribbon synapse of the photoreceptors
  • role of RIMS2 in regulating synaptic membrane exocytosis in the brain, pancreas, and photoreceptors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB3A
  • interacting with RIMBP2 and BZRAP1
  • contributes to the stabilization of CACNA1D gating kinetics in immature cochlear inner hair cell
  • PNKD interacts with synaptic active zone proteins Rab3-interacting molecule (RIMS1) and RIMS2, localizes to synapses, and modulates neurotransmitter release
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CRSDS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS