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FLASH GENE

Symbol

RBM7

contributors: SGE/npt - updated : 22-07-2010

HGNC name	RNA binding motif protein 7
HGNC id	9904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.2      Physical location : 114.271.383 - 114.279.632
Synonym symbol(s)	FLJ11153

DNA

TYPE	functioning gene
STRUCTURE	8.25 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016090 5 - 2025 NP_057174 - 266 - Guo (2003)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one RRM domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Rrm7 (83.8pc)
	homolog to rattus Rrm7 (83.4pc)

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	ZCCHC8 and RBM7 are excluded from nucleoli

basic FUNCTION	may be a pre-mRNA splicing factor
	may be involved in germ cell RNA processing and meiosis (Guo 2003)

CELLULAR PROCESS	cell cycle,division,meiosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of the trimeric Nuclear Exosome Targeting (NEXT) complex, containing SKIV2L2, the Zn-knuckle protein ZCCHC8, and the putative RNA binding protein RBM7

INTERACTION

DNA

RNA

binding

small molecule

protein

interacting with SF3B2 and SFRS3 (Guo 2003)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS