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FLASH GENE
Symbol RAX contributors: mct/npt - updated : 03-04-2018
HGNC name retina and anterior neural fold homeobox
HGNC id 18662
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved paired-like homeodomain
  • an octopeptide typical of this homeo box gene subfamily
  • one OAR domain
    • HOMOLOGY
    interspecies homolog to rattus Rax
    ortholog to murine Rax
    Homologene
    FAMILY
  • paired homeobox family
  • bicoid subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation
  • essential for vertebrate eye development
  • its function is required for the specification and maintenance of retinal progenitor cells
  • is also necessary during retinal regeneration
  • potentially contributes to phenotype maintenance in the mature retina and pineal gland
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text eye development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with embryonic enhancer locus for photoreceptor OTX2 transcription to transactivate OTX2, mainly in the final cell cycle of retinal progenitors
  • LHX2 is a key intrinsic regulator of tanycyte differentiation, sustaining RAX-dependent activation of tanycyte-specific genes while also inhibiting expression of ependymal cell-specific genes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCOP3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS